Mind-body practices enjoy immense public and scientific interest. Yoga and meditation are highly popular. Purportedly, they foster well-being by “quieting the ego” or, more specifically, curtailing self-enhancement. However, this ego-quieting effect contradicts an apparent psychological universal, the self-centrality principle. According to this principle, practicing any skill renders it self-central, and self-centrality breeds self-enhancement. We examined those opposing predictions in the first tests of mind-body practices’ self-enhancement effects. Experiment 1 followed 93 yoga students over 15 weeks, assessing self-centrality and self-enhancement after yoga practice (yoga condition, n=246) and without practice (control condition, n=231). Experiment 2 followed 162 meditators over 4 weeks (meditation condition: n=246; control condition: n=245). Self-enhancement was higher in the yoga (Experiment 1) and meditation (Experiment 2) conditions, and those effects were mediated by greater self-centrality. Additionally, greater self-enhancement mediated mind-body practices’ well-being benefits. Evidently, neither yoga nor meditation quiet the ego; instead, they boost self-enhancement.